EFFECTIVE ROLE OF THE PROPOLIS AGAINST HEPATOCELLULAR DAMAGE OF TOXIC DRUGS IN ALBINO RATS

Abstract

Objective: The main purpose of this study is to evaluate the hepatoprotective effects of propolis in hepatocyte injury caused by Anti-tuberculosis treatment (ATT) due to isoniazid and rifampicin.

Methodology: Healthy albino rats with an average weight of 200-250g were included in this study. These rats were divided into main four groups, a group was taken as the control group and then the rest were group B, group C, and group D, designated as experimental groups. The control group had 15 rats with measured weight, they were given distilled water. Group B had 15 rats, they were given with standard dose of rifampicin and isoniazid. Group C had 15 rats, they were also given with standard dose of rifampicin and isoniazid. Group D had 15 rats, they were given a standard dose of rifampicin and isoniazid and also the extract of the propolis we given to this group.

Results: Serum ALT level in experimental group B with group C, and group D was also found to be statistically significant with a p-value < 0.001. ALT serum level was observed high in group B. Multiple comparisons between groups revealed that group B with a significant increase in the serum enzyme AST level in comparison to group A, group C, and group D with p-value <0.001.

Conclusion: This study showed that ethanolic extract of propolis prevents isoniazid and rifampicin-induced hepatotoxicity in albino rats.

Keywords: Propolis, Liver Function Test (LFTs), Anti-tuberculosis treatment (ATTs), Hepato-toxicity, antioxidant, ALT, AST

Cite this Article as: Arshad A., Haq I. , Pervaiz S., Haleema S., Ahsan U., Iqbal S., Shamim S., Ahmad K.,; Effective Role of the Propolis against Hepatocellular Damage of Toxic Drugs in Albino Rats.; SIAL J Med. Sci. Sept-2024 V-3 (Issue-09):12-18

Submission completed: April, 2024

Review began: April, 2024

Review ended: May, 2024,

Accepted: June, 2024

Published: September, 2024